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Correlation between diabetic retinopathy and c-reactive protein in patients with type 2 diabetes mellitus

Sari Marina , Putu Budiastra, Ari Andayani

Sari Marina
Ophthalmology Department, Faculty of Medicine Udayana University/ Sanglah General Hospital, Bali. Email: ririnsarimarina@yahoo.com

Putu Budiastra
Ophthalmology Department, Faculty of Medicine Udayana University/ Sanglah General Hospital, Bali

Ari Andayani
Ophthalmology Department, Faculty of Medicine Udayana University/ Sanglah General Hospital, Bali
Online First: January 06, 2018 | Cite this Article
Marina, S., Budiastra, P., Andayani, A. 2018. Correlation between diabetic retinopathy and c-reactive protein in patients with type 2 diabetes mellitus. Bali Journal of Ophthalmology 2(1): 1-5. DOI:10.15562/bjo.v2i1.9


Background: Diabetic Retinopathy (DR) is one of the complications due to diabetes mellitus (DM). Pathogenesis of DR is microvascular disorder because of long term hyperglycemia. The trigger mechanism is activated by metabolic pathways, oxidative stress and inflammation. C-reactive protein (CRP) is one of the inflammatory markers. This study aims to determine the correlation between CRP level and stagging of DR.

Method: This study was a cross-sectional study in Sanglah eye clinic, in August until October 2017, a total of 51 sample with DR. The samples were categorized based on DR staging, namely Non Diabetic Retinopathy (NDR), Non-Proliferative Diabetic Retinopathy (NPDR), and Proliferative Diabetic Retinopathy (PDR) respectively. Each group of staging was performed CRP examination. This study assessed the correlation between CRP levels and staging of DR using Spearman correlation test.

Result: The result of this study obtained correlation coefficient (r) value of 0,396 (p=0,004), showed positive correlation between CRP level and staging Of DR. The regression equation correlation between CRP level and DR staging is expressed by regression equation: CRP = 0,119 + 0,847 (DR staging), this equation shows that if not found DR (NDR=0), CRP level 0,119 mg/L, each 1 staging increase of DR will decrease 0,847 mg/L CRP levels. The correlation between CRP level and DR staging after controlled with independent variables obtained by DR was correlated significantly with DR staging (p=0,037).

Conclusion: This study showed there is positive correlation between plasma CRP levels and the staging of DR, increasing level of CRP correlated with increasing staging of DR.

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