Evaluation of Peripapillary RNFL (Retinal Nerve Fiber Layer) in sickle cell disease

Snehal Bonde Chaurasiya, Swarna Naresh Gaikwad

Snehal Bonde Chaurasiya
associate professor,GMCH, Nagpur

Swarna Naresh Gaikwad
junior resident MCH, Nagpur. Email:
Online First: March 26, 2019 | Cite this Article
Chaurasiya, S., Gaikwad, S. 2019. Evaluation of Peripapillary RNFL (Retinal Nerve Fiber Layer) in sickle cell disease. Bali Journal of Ophthalmology 2(2): 44-46. DOI:10.15562/bjo.v2i2.26


Aim: To evaluate peripapillary retinal nerve fiber layer thickness (RNFL) in patients with sickle cell disease by optical coherence tomography(OCT).

METHOD:It was a clinical, prospective study.50 Sickle cell disease (SCD) patients & 50 controls included. Glaucoma & other ocular diseases were excluded. Complete ophthalmic evaluation & OCT was done. Through which 2 groups: focal macular thinning & no macular thinning made. Peripapillary RNFL thickness was assessed.

RESULT: Sickle Cell patients with macular thinning had thinner mean peripapillary RNFL thickness in nasal sector compared with control eyes & in superotemporal sector compared with Sickle Cell patient eyes without macular thinning. In severe macular thinning, mean peripapillary RNFL thickness was significantly thinner than controls.

CONCLUSION:Sickle Cell patients without glaucoma & with focal macular thinning have thinner peripapillary RNFL than controls & those without macular thinning. Degree of RNFL thinning correlates with severity of temporal macular thinning. These patients may require different peripapillary RNFL thickness thresholds for future glaucoma evaluations.


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